Many slots players hear that prizes are awarded based on a random number generator.  And when you hear the term "random number generator" it makes some kind of sense like a computer program that scrambles numbers.  However, most people aren't exactly familiar with what a random number generator (a.k.a. RNG) actually is.

The basic definition of a random number generator is a sequence of numbers that have no pattern - thus the "random" part.  And these random number sequences are made through the usage of algorithms.  If you're unfamiliar with an algorithm, it is simply a math equation designed to solve a certain problem.  Of course, it's not necessarily a "problem," but rather a means to enact a specific program such as email advertisements that match up with your personal email details (the algorithms match specific ads to the correct people).

In the case of slots, the algorithms are designed to randomly award prizes to players while staying true to payout percentages.  The fact that the algorithms are so random means slots players have no chance of determining a pattern in the payouts.  So even though a game may offer 98% payouts, one might play anywhere from 30 spins to 30,000 spins to finally achieve this payout percentage. 

Basically what all of this means is that you have literally no chance of ever beating a slots machine through wager timing or bet sizing.  When you click the mouse in online slots, you are merely letting the machine know that you're ready for random numbers to appear.  The random numbers won't be affected by your betting size or anything else so there's no point in trying to beat a random number generator.